Le jeûne (juste une mode ?), avec Axel Sedano

00:00:00 Introduction de l'épisode sur le jeûne avec Axel

00:01:15 Présentation d'Axel Sedano, diététicien

00:02:30 Définition du jeûne

00:04:00 Types de jeûne expliqués

00:06:45 Popularité du jeûne intermittent

00:09:00 Impact du repas sauté dans le jeûne intermittent

00:11:30 Effets similaires du jeûne et de la restriction calorique

00:13:45 Jeûne pour raisons religieuses ou idéologiques

00:15:00 Autophagie et nettoyage cellulaire

00:18:30 Détoxification et jeûne: faits et mythes

00:21:00 Approches basées sur des preuves pour la santé du foie

00:23:00 Effets du jeûne intermittent sur la santé métabolique

00:26:00 Impact du jeûne sur la perte de poids et l'exercice

00:29:00 Jeûne et gain musculaire

00:31:30 Jeûne et santé digestive

00:34:00 Impact du jeûne sur le microbiome

00:36:30 Jeûne et vieillissement

00:38:00 Jeûne et cancer: tolérance à la chimiothérapie

00:41:00 Effet Warburg et cellules tumorales

00:44:00 Recommandations médicales pour le jeûne

00:46:00 Sources fiables d'information sur le jeûne

00:48:00 Dangers du jeûne et pratiques sectaires

00:50:00 Recommandations de lecture et suivi d'Axel

Retrouvez Axel sur instagram :

https://www.instagram.com/sedanoaxel/

Resources :

1) Risque des Cures de jeûne et emprise sectaire :

Afis Science - Association française pour l’information scientifique. (2015.). https://www.afis.org/Cures-detox-intox

Bras, L. (2021, August 4). Jeûne extrême, crudivorisme. . . Les pratiques sectaires santé et bien-être en forte augmentation. Ouest-France.fr. https://www.ouest-france.fr/societe/crudivorisme-jeune-extreme-les-pratiques-sectaires-sante-et-bien-etre-en-forte-augmentation-09290636-f437-11eb-be44-3c3b5e3aae9e

Laurent, S. (2023, January 14). Un naturopathe promoteur du jeûne mis en examen pour « homicide involontaire ». Le Monde.fr. https://www.lemonde.fr/societe/article/2023/01/13/un-naturopathe-promoteur-du-jeune-mis-en-examen-pour-homicide-involontaire_6157797_3224.html

2) Études et méta-analyses sur la perte de poids et les marqueurs cardio-métaboliques :

Allaf, M., Elghazaly, H., Mohamed, O. G., Fareen, M. F. K., Zaman, S., Salmasi, A., Tsilidis, K., & Dehghan, A. (2021). Intermittent fasting for the prevention of cardiovascular disease. Cochrane Library, 2021(3). https://doi.org/10.1002/14651858.cd013496.pub2

Chen, J., Lu, L. W., Ge, Q., Feng, D., Yu, J., Liu, B., Zhang, R., Zhang, X., Ouyang, C., & Chen, F. (2021). Missing puzzle pieces of time-restricted-eating (TRE) as a long-term weight-loss strategy in overweight and obese people? A systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 63(15), 2331–2347. https://doi.org/10.1080/10408398.2021.1974335

Schroor, M. M., Joris, P. J., Plat, J., & Mensink, R. P. (2023). Effects of Intermittent Energy Restriction Compared with Those of Continuous Energy Restriction on Body Composition and Cardiometabolic Risk Markers – A Systematic Review and Meta-Analysis of Randomized Controlled Trials in Adults. Advances in Nutrition, 100130. https://doi.org/10.1016/j.advnut.2023.10.003

Silverii, G. A., Cresci, B., Benvenuti, F., Santagiuliana, F., Rotella, F., & Mannucci, E. (2023). Effectiveness of intermittent fasting for weight loss in individuals with obesity: A meta-analysis of randomized controlled trials. Nutrition Metabolism and Cardiovascular Diseases, 33(8), 1481–1489.

https://doi.org/10.1016/j.numecd.2023.05.005

Sun, M., Yao, W., Wang, X., Gao, S., Varady, K. A., Forslund, S. K., Zhang, M., Shi, Z., Cao, F., Zou, B., Sun, M., Liu, K., Bao, Q., Xu, J., Qin, X., Xiao, Q., Wu, L., Zhao, Y., Zhang, D., . . . Gong, T. (2024). Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials. EClinicalMedicine, 70, 102519. https://doi.org/10.1016/j.eclinm.2024.102519

Sutton, E. F., Beyl, R., Early, K. S., Cefalu, W. T., Ravussin, E., & Peterson, C. M. (2018). Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metabolism, 27(6), 1212-1221.e3. https://doi.org/10.1016/j.cmet.2018.04.010

Varady, K. A., Cienfuegos, S., Ezpeleta, M., & Gabel, K. (2022). Clinical application of intermittent fasting for weight loss: progress and future directions. Nature Reviews Endocrinology, 18(5), 309–321. https://doi.org/10.1038/s41574-022-00638-x

Xie, Y., Zhou, K., Shang, Z., Bao, D., & Zhou, J. (2024). The Effects of Time-Restricted Eating on Fat Loss in Adults with Overweight and Obese Depend upon the Eating Window and Intervention Strategies: A Systematic Review and Meta-Analysis. Nutrients, 16(19), 3390. https://doi.org/10.3390/nu16193390

3) Meta-analyses sur le jeûne et le stress oxydatif et l’inflammation:

Mohr, A. E., McEvoy, C., Sears, D. D., Arciero, P. J., & Sweazea, K. L. (2021). Impact of intermittent fasting regimens on circulating markers of oxidative stress in overweight and obese humans: A systematic review of randomized controlled trials. Advances in Redox Research, 3, 100026. https://doi.org/10.1016/j.arres.2021.100026

Turner, L., Charrouf, R., Martínez-Vizcaíno, V., Hutchison, A., Heilbronn, L. K., & Fernández-Rodríguez, R. (2023). The effects of time-restricted eating versus habitual diet on inflammatory cytokines and adipokines in the general adult population: a systematic review with meta-analysis. American Journal of Clinical Nutrition, 119(1), 206–220. https://doi.org/10.1016/j.ajcnut.2023.10.009

Wang, X., Yang, Q., Liao, Q., Li, M., Zhang, P., Santos, H. O., Kord-Varkaneh, H., & Abshirini, M. (2020). Effects of intermittent fasting diets on plasma concentrations of inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials. Nutrition, 79–80, 110974. https://doi.org/10.1016/j.nut.2020.110974

4) Études sur le sport à jeun et sur la prise de muscle :

Keenan, S., Cooke, M. B., & Belski, R. (2020). The Effects of Intermittent Fasting Combined with Resistance Training on Lean Body Mass: A Systematic Review of Human Studies. Nutrients, 12(8), 2349. https://doi.org/10.3390/nu12082349

Keenan, S. J., Cooke, M. B., Hassan, E. B., Chen, W. S., Sullivan, J., Wu, S. X., El-Ansary, D., Imani, M., & Belski, R. (2022). Intermittent fasting and continuous energy restriction result in similar changes in body composition and muscle strength when combined with a 12 week resistance training program. European Journal of Nutrition, 61(4), 2183–2199. https://doi.org/10.1007/s00394-022-02804-3

Tinsley, G. M., Moore, M. L., Graybeal, A. J., Paoli, A., Kim, Y., Gonzales, J. U., Harry, J. R., VanDusseldorp, T. A., Kennedy, D. N., & Cruz, M. R. (2019). Time-restricted feeding plus resistance training in active females: a randomized trial. American Journal of Clinical Nutrition, 110(3), 628–640. https://doi.org/10.1093/ajcn/nqz126

Tremblay, A., Simoneau, J., & Bouchard, C. (1994). Impact of exercise intensity on body fatness and skeletal muscle metabolism. Metabolism, 43(7), 814–818. https://doi.org/10.1016/0026-0495(94)90259-3

Schoenfeld, B. J., Aragon, A. A., Wilborn, C. D., Krieger, J. W., & Sonmez, G. T. (2014). Body composition changes associated with fasted versus non-fasted aerobic exercise. Journal of the International Society of Sports Nutrition, 11(1). https://doi.org/10.1186/s12970-014-0054-7

5) Études sur les maladies digestives :

Études chez l’animal : 

Song, S., Bai, M., Ling, Z., Lin, Y., Wang, S., & Chen, Y. (2021). Intermittent administration of a fasting-mimicking diet reduces intestinal inflammation and promotes repair to ameliorate inflammatory bowel disease in mice. The Journal of Nutritional Biochemistry, 96, 108785. https://doi.org/10.1016/j.jnutbio.2021.108785

Rapport de cas chez l'homme et les MICI :

Roco-Videla, Á., Villota-Arcos, C., Pino-Astorga, C., Mendoza-Puga, D., Bittner-Ortega, M., & Corbeaux-Ascui, T. (2023). Intermittent Fasting and Reduction of Inflammatory Response in a Patient with Ulcerative Colitis. Medicina, 59(8), 1453. https://doi.org/10.3390/medicina59081453

6) Rapports et méta-analyses sur le jeûne et le cancer :

Clifton, K. K., X, C., MA, Fontana, L., & Peterson, L. L. (2021). Intermittent fasting in the prevention and treatment of cancer. CA a Cancer Journal for Clinicians, 71(6), 527–546. https://doi.org/10.3322/caac.21694

De Groot, S., Vreeswijk, M. P., Welters, M. J., Gravesteijn, G., Boei, J. J., Jochems, A., Houtsma, D., Putter, H., Van Der Hoeven, J. J., Nortier, J. W., Pijl, H., & Kroep, J. R. (2015). The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study. BMC Cancer, 15(1). https://doi.org/10.1186/s12885-015-1663-5

Drexler, U., Dörfler, J., Von Grundherr, J., Erickson, N., & Hübner, J. (2022). Fasting during cancer treatment: a systematic review. Quality of Life Research, 32(5), 1427–1446. https://doi.org/10.1007/s11136-022-03300-1

NACRe. (2017). Rapport NACRe jeune regimes restrictifs cancer 2017. https://www.reseaunacre.eu/actualites/rapport-nacre-jeune-regimes-restrictifs-cancer-2017

Stringer, E. J., Cloke, R. W. G., Van Der Meer, L., Murphy, R. A., Macpherson, N. A., & Lum, J. J. (2024). The Clinical Impact of time-restricted eating on Cancer: A Systematic review. Nutrition Reviews. https://doi.org/10.1093/nutrit/nuae105

Études sur les régimes qui imittent le jeûne :

De Groot, S., Lugtenberg, R. T., Cohen, D., Welters, M. J. P., Ehsan, I., Vreeswijk, M. P. G., Smit, V. T. H. B. M., De Graaf, H., Heijns, J. B., Portielje, J. E. A., Van De Wouw, A. J., Imholz, A. L. T., Kessels, L. W., Vrijaldenhoven, S., Baars, A., Kranenbarg, E. M., Carpentier, M. D., Putter, H., Van Der Hoeven, J. J. M., . . . Kroep, J. R. (2020). Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-16138-3

Lugtenberg, R. T., De Groot, S., Kaptein, A. A., Fischer, M. J., Kranenbarg, E. M., Carpentier, M. D., Cohen, D., De Graaf, H., Heijns, J. B., Portielje, J. E. A., Van De Wouw, A. J., Imholz, A. L. T., Kessels, L. W., Vrijaldenhoven, S., Baars, A., Fiocco, M., Van Der Hoeven, J. J. M., Gelderblom, H., Longo, V. D., . . . Kroep, J. R. (2020). Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013–14) trial. Breast Cancer Research and Treatment, 185(3), 741–758. https://doi.org/10.1007/s10549-020-05991-x

L’autophagie : 

Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., Rubinsztein, D. C., Partridge, L., Kroemer, G., Labbadia, J., & Fang, E. F. (2021). Autophagy in healthy aging and disease. Nature Aging, 1(8), 634–650. https://doi.org/10.1038/s43587-021-00098-4

Lim, S. M., Hanif, E. a. M., & Chin, S. (2021). Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect. Cell & Bioscience, 11(1). https://doi.org/10.1186/s13578-021-00570-z

Le prix Nobel Yoshinori Ohsumi n’a pas recommandé le jeûne pour guérir le cancer et Alzheimer. (2022, May 6). Factuel. https://factuel.afp.com/doc.afp.com.32L47ZC

L’effet Warburg : 

DeBerardinis, R. J., & Chandel, N. S. (2020). We need to talk about the Warburg effect. Nature Metabolism, 2(2), 127–129. https://doi.org/10.1038/s42255-020-0172-2

Liberti, M. V., & Locasale, J. W. (2016). The Warburg Effect: How Does it Benefit Cancer Cells? Trends in Biochemical Sciences, 41(3), 211–218. https://doi.org/10.1016/j.tibs.2015.12.001

7) Études sur le vieillissement et le jeûne chez l'animal :

Harper, J. M., Leathers, C. W., & Austad, S. N. (2006). Does caloric restriction extend life in wild mice? Aging Cell, 5(6), 441–449. https://doi.org/10.1111/j.1474-9726.2006.00236.x

Pak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., Johnson, M., Barnes, S., Darley-Usmar, V., Zhang, J., Yen, C. E., Denu, J. M., & Lamming, D. W. (2021). Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice. Nature Metabolism, 3(10), 1327–1341. https://doi.org/10.1038/s42255-021-00466-9

8) Microbiote et santé ?

Arsenault, B., & Gagnon, É. (n.d.). Notre microbiote intestinal exerce-t-il vraiment une influence sur notre santé et notre espérance de vie  ? The Conversation. https://theconversation.com/notre-microbiote-intestinal-exerce-t-il-vraiment-une-influence-sur-notre-sante-et-notre-esperance-de-vie-196709

Gagnon, E., Mitchell, P. L., Manikpurage, H. D., Abner, E., Taba, N., Esko, T., Ghodsian, N., Thériault, S., Mathieu, P., & Arsenault, B. J. (2023). Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study. Journal of Translational Medicine, 21(1). https://doi.org/10.1186/s12967-022-03799-5

9) Études sur les corps cétoniques et la satiété :

Gibson, A. A., Seimon, R. V., Lee, C. M. Y., Ayre, J., Franklin, J., Markovic, T. P., Caterson, I. D., & Sainsbury, A. (2014). Do ketogenic diets really suppress appetite? A systematic review and meta‐analysis. Obesity Reviews, 16(1), 64–76. https://doi.org/10.1111/obr.12230

Stubbs, B. J., Cox, P. J., Evans, R. D., Cyranka, M., Clarke, K., & De Wet, H. (2017). A ketone ester drink lowers human ghrelin and appetite. Obesity, 26(2), 269–273. https://doi.org/10.1002/oby.22051